Home  >  Products  >  SHC (Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein C1, SHC-transforming Protein 1, SHC1, FLJ26504, SHC-transforming Protein 3, SHC-transforming Protein A, SHCA)
SHC (Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein C1, SHC-transforming Protein 1, SHC1, FLJ26504, SHC-transforming Protein 3, SHC-transforming Protein A, SHCA)

SHC (Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein C1, SHC-transforming Protein 1, SHC1, FLJ26504, SHC-transforming Protein 3, SHC-transforming Protein A, SHCA)

Cat no: S1010-90Q

Supplier: United States Biological
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The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then, a number of studies in multiple systems have implicated a role for Shc in many different types of signal transduction including growth factor, antigen, cytokine, G-protein, hormone, and integrin receptor signaling. In addition to the ubiquitous ShcA, there are two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. An important role for Shc in the activation of MAPK pathway has been established. Thus, Shc adapter proteins are critical components of signal transduction pathways involved in many different cellular processes. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Jurkat, HeLa, and SKN-SH cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1010-90Q
Reactivities: Human, Mouse, Rat, Rabbit
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide, 50% gylcerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: SHC (Src Homology 2 Domain Containing) Transforming Protein 1
Additional info: Recognizes human ShcA. Species Crossreactivity: rat, mouse, rabbit.

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