Home  >  Products  >  SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SH3 and Multiple Ankyrin Repeat Domains Protein 1, GKAP/SAPAP-interacting Protein, Somatostatin Receptor Interacting Protein, SPANK1, SPANK-1, SSTR-interacting Protein, SSTRIP, Synamon)

SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SH3 and Multiple Ankyrin Repeat Domains Protein 1, GKAP/SAPAP-interacting Protein, Somatostatin Receptor Interacting Protein, SPANK1, SPANK-1, SSTR-interacting Protein, SSTRIP, Synamon)

Cat no: S1010-88A8


Supplier: United States Biological
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Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasmic; postsynaptic density of neuronal cells. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1010-88A8
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: Naisbitt et al. (1999). Neuron. 23:569-582.
Additional info: Reacts with residues [ERLLREYPQSFEKGV] of the N terminus of the rat Shank1a protein. Species Crossreactivity: Reacts with human and rat Shank1a. Does not react with mouse Shank1a.

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