Home  >  Products  >  SH3 and PX domain-containing protein 2B (SH3PXD2B, Factor for adipocyte differentiation 49, SH3 and PX domains 2B, Factor for adipocyte differentiation 49, Fad49, KIAA1295)
SH3 and PX domain-containing protein 2B (SH3PXD2B, Factor for adipocyte differentiation 49, SH3 and PX domains 2B, Factor for adipocyte differentiation 49, Fad49, KIAA1295)

SH3 and PX domain-containing protein 2B (SH3PXD2B, Factor for adipocyte differentiation 49, SH3 and PX domains 2B, Factor for adipocyte differentiation 49, Fad49, KIAA1295)

Cat no: S1013-33B

Supplier: United States Biological
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SH3PXD2B is a novel adaptor protein; also known as SH3 and PX domain-containing protein 2B, (Courtneidge, 2005). It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). Additionally, SH3PXD2B may be involved in the recruitment of MT1-MMP and ECM degradation. SH3PXD2B is broadly expressed and localizes in the cytoplasm of the podosome. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: NIH3T3 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1013-33B
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Pab
Purity: Purified by Protein A affinity chromatography.
References: 1. Buschman, M.D., et al., (2009). Mol. Cell Biol. 20(5):1302-1311. 2. Courtneidge, S.A., et al., (2005). Cold Spring Harb Symp Quant Biol. 70:167-171.
Additional info: Recognizes human SH3PXD2B. Species Crossreactivity: mouse. Species sequence homology: rat (77%).

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