SDF1 is a 93aa cytokine belonging to the intercrine alpha (chemokine CxC) family and consisting of 4 conserved cysteines which form 2 disulfide bonds that activate leukocytes and are induced by proinflammatory stimuli like lipopolysaccharide, TNF or IL1. Two splice forms have been identified, SDF-1 alpha and SDF-1 beta. It is involved in astrocyte division, MAP kinase signal transduction and also trigges protein kinase C, zeta phosphorylation, translocation to the plasma membrane and kinase activity. It functions as an autocrine and paracrine mucosal signaling network regulating the epithelial barrier to withstand injury and mediate repair following damage. It induces MMP-13 expression in human chondrocytes and may influence tumor progression. It is expressed in myocardium, bone marrow and skeletal muscle.
Suitable for use in ELISA. Other applications not tested.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.