Home  >  Products  >  S1PR2 (Sphingosine 1-phosphate Receptor 2, S1P Receptor 2, S1P2, Endothelial Differentiation G-protein Coupled Receptor 5, Sphingosine 1-phosphate Receptor Edg-5, S1P Receptor Edg-5, Edg5)
S1PR2 (Sphingosine 1-phosphate Receptor 2, S1P Receptor 2, S1P2, Endothelial Differentiation G-protein Coupled Receptor 5, Sphingosine 1-phosphate Receptor Edg-5, S1P Receptor Edg-5, Edg5)

S1PR2 (Sphingosine 1-phosphate Receptor 2, S1P Receptor 2, S1P2, Endothelial Differentiation G-protein Coupled Receptor 5, Sphingosine 1-phosphate Receptor Edg-5, S1P Receptor Edg-5, Edg5)

Cat no: S5451-05A

Supplier: United States Biological
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S1P2 is a membrane protein belonging to the EDG family of extracellular G protein coupled receptors. It acts as a receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) and participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It shares 92% aa identity with rat H218 and approximately 44% identity with the human S1P receptors Edg1 and Edg3. Though the role of S1P2 in vascular permeability is not clear, reports suggest that it regulates PTEN by a Rho GTPase-dependent pathway to inhibit cell migration. S1P2 also plays an important role in normal vascularization and hypoxia-triggered pathological angiogenesis of the mouse retina. The gene for human S1P2 protein is localized on chromosomal region 19p13.2. The protein is usually expressed in human brain and heart. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Heart Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5451-05A
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. MacLennan, AJ. et al. Mole. Cell. Neurosci. 5:201-209 (1994). 2. An, S. et al. J. Biol. Chem. 275:288-296 (2000). 3. Denise, L. et al. Cancer Research. 65:3788-3795 (2005).
Additional info: Recognizes human S1P2. Species Crossreactivity: monkey, mouse, rat.

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