Home  >  Products  >  Prealbumin (PALB, Amyloid Polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic Euthyroidal Hyperthyroxinemia, Dystransthyretinemic Hyperthyroxinemia, HsT2651, Prealbumin Amyloidosis Type I, Senile Systemic Amyloidosis, TBPA, Transthyretin, TTR, TTR Prot
Prealbumin (PALB, Amyloid Polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic Euthyroidal Hyperthyroxinemia, Dystransthyretinemic Hyperthyroxinemia, HsT2651, Prealbumin Amyloidosis Type I, Senile Systemic Amyloidosis, TBPA, Transthyretin, TTR, TTR Prot

Prealbumin (PALB, Amyloid Polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic Euthyroidal Hyperthyroxinemia, Dystransthyretinemic Hyperthyroxinemia, HsT2651, Prealbumin Amyloidosis Type I, Senile Systemic Amyloidosis, TBPA, Transthyretin, TTR, TTR Prot

Cat no: P6000-06A

Supplier: United States Biological
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Prealbumin (TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Prealbumin concentrations are disproportionately high in human ventricular cerebrospinal fluid (CSF). It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in prealbumin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of prealbumin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble prealbumin fibrils (2). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 Immunohistochemistry: 1:100-1:250 Flow Cytometry: 1:80 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: P6000-06A
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Klabunde T, et al. Nat Struct Biol. 7(4):312-21, 2000 2. Herbert J, et al. Neurology 36(7):900-11, 1986 3. Saraiva MJ Hum Mutat. 17(6):493-503, 2001
Additional info: Recognizes human Prealbumin

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