Home  >  Products  >  PNPLA2 (Patatin-like Phospholipase Domain-containing Protein 2, Adipose Triglyceride Lipase, Calcium-independent Phospholipase A2, Desnutrin, IPLA2-zeta, Pigment Epithelium-derived Factor, TTS2.2, Transport-secretion Protein 2, TTS2, ATGL, FP17548)

PNPLA2 (Patatin-like Phospholipase Domain-containing Protein 2, Adipose Triglyceride Lipase, Calcium-independent Phospholipase A2, Desnutrin, IPLA2-zeta, Pigment Epithelium-derived Factor, TTS2.2, Transport-secretion Protein 2, TTS2, ATGL, FP17548)

Cat no: P4350-15A


Supplier: United States Biological
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Triglycerides form an important energy store in many living organisms. Adipose tissue serves as the primary storage depot for triglycerides in mammals. Lipolytic enzymes mobilize triglycerides during periods of starvation to provide organisms with necessary energy. Hormone-sensitive lipase (HSL), the first identified lipolytic enzyme, hydrolyzes triglycerides in mammalian adipose tissues. Additional lipolytic enzymes, including adipose triglyceride lipase (ATGL), have also been discovered. The primary function of ATGL is to catalyze the hydrolysis of the first ester bond of lipid molecules. This enzyme may provide diglyceride substrates for HSL hydrolysis. ATGL is abundantly expressed in murine white and brown adipose tissue, and is highly substrate specific. ATGL was independently identified as desnutrin and the TG-hydrolace inducible phospholipase-A2-z. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P4350-15A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human ATGL at ~54kD. Species Crossreactivity: mouse and rat.

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