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Platencin

Platencin

Cat no: P4262

Supplier: United States Biological
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Platencin is a more potent analogue of Platensimycin also discovered from a strain of Streptomyces platensis. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF. Source: Platencin Molecular Weight: ~425.2 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P4262
Size: 100ug
Form: Supplied as a light tan solid.
Purity: (same/more than) 95% by HPLC
References: 1. Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity. Jayasuriya, H., et al., Angew. Chem. Int. Ed. 46: 4684 (2007). 2. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Wang, J., et al., PNAS 104: 7612 (2007).

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