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Products PINK1 Polyclonal Antibody
| Catalogue number: | 10006283 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human PINK1 amino acids 484-504 (LVRALLQREASKRPSARVAAN) |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Phosphatase and Tensin Homolog (PTEN) dephosphorylates lipids such as phosphatidylinositol 3,4,5-triphosphate (PIP3) and its defects contribute to a variety of human cancers. PTEN induced putative kinase 1 (PINK1) was first identified when studying the tumor-suppressive function of the PTEN signaling pathway and is thus believed to be involved in human cancer pathology. The mRNA of PINK1 is expressed ubiquitously among adult tissues with most abundant expression in the heart, skeletal muscle, and testis. PINK1 is located in mitochondria and its homozygous C-terminus mutation is associated with early onset of Parkinson's disease. Cayman's PINK1 polyclonal antibody recognizes primarily the full length protein at about 66 kDa in human, mouse, and rat tissues. In addition, a truncated form of the protein at about 33 kDa is also detected. |
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