Home  >  Products  >  NQO1 (NAD(P)H Dehydrogenase Quinone 1, Azoreductase, Cytochrome b-5 Reductase, DHQU, Diaphorase (NADH/NADPH) (Cytochrome b-5 Reductase), Diaphorase 4, DIA4, Dioxin Inducible 1, DT Diaphorase, DTD, Menadione Reductase, NAD(P)H Menadione Oxidoreductase 1 Di
NQO1 (NAD(P)H Dehydrogenase Quinone 1, Azoreductase, Cytochrome b-5 Reductase, DHQU, Diaphorase (NADH/NADPH) (Cytochrome b-5 Reductase), Diaphorase 4, DIA4, Dioxin Inducible 1, DT Diaphorase, DTD, Menadione Reductase, NAD(P)H Menadione Oxidoreductase 1 Di

NQO1 (NAD(P)H Dehydrogenase Quinone 1, Azoreductase, Cytochrome b-5 Reductase, DHQU, Diaphorase (NADH/NADPH) (Cytochrome b-5 Reductase), Diaphorase 4, DIA4, Dioxin Inducible 1, DT Diaphorase, DTD, Menadione Reductase, NAD(P)H Menadione Oxidoreductase 1 Di

Cat no: N5379-50B

Supplier: United States Biological
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NQO1 is a 2-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Individuals homozygous for the T/T form of the 609C-T polymorphism have an increased risk of benzene hematotoxicity. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasmic (primarily), nuclear (faintly) Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: N5379-50B
Reactivities: Human, Rat, Canine, Non-Human Primate
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Tris-glycine and 150mM sodium chloride.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Siegel, et al. Clinical Can. Res. 4:2065-2070 (1998) 2. Siegel, et al. Free Radical Biol. Med. 29:246-253 (2000) 3. Slitt, A. L., Cherrington, N. J., Dieter, M. Z., Aleksunes, L. M., Scheffer, G. L., Huang, W., Moore, D. D., and Klaassen, C. D. (2006) trans-Stilbene Oxide Induces Expression of Genes Involved in Metabolism and Transport in Mouse Liver via CAR and Nrf2 Transcription Factors, 69, 1554-1563.
Additional info: Specific for NQO1. It does not crossreact with NQO2. Species Crossreactivity: human and rat. Crossreacts with monkey and canine in immunohistochemistry. Cross-reactivity with mouse is extremely poor.

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