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Neu, BioAssay(TM) Kitronal Transdifferentiation Modulators Set III

Cat no: N2174-20B

Supplier: United States Biological
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A convenient set of four small molecule modulators for enhancing neuronal transdifferentiation. The four products are: SB-431542 (Cat #S0098-93), LDN193189, CHIR99021 and Noggin, human recombinant. Set Contents: SB-431542 (Cat #S0098-93): TGF-b1 receptor ALK5 inhibitor (1x1mg) LDN193189: BMP type I receptors ALK2 and ALK3 inhibitor (1x1mg) CHIR99021: GSK-3b inhibitor (1x1mg) Noggin, human recombinant: Inhibits TGF-b signal transduction by binding to TGF-b family ligands. BMP4 antagonist. (1x20ug) Solubility: SB-431542, LDN193189 and CHIR99021 are soluble in DMSO (~20mg/ml) or Ethanol (~2mg/ml), DMSO (~4.5mg/ml) and DMSO (~46.5mg/ml) respectively. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: N2174-20B
Size: 1 Set
Form: Supplied as a lyophilized solid.
Purity: ~95% (HPLC)
References: 1. Ladewig J., Mertens J. et.al (2012), Apr 8. Nature Methods doi:10.1038/nmeth.1972 [Epub ahead of print]

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