Home  >  Products  >  Mucin 1, isoform 7 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Seque
Mucin 1, isoform 7 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Seque

Mucin 1, isoform 7 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Seque

Cat no: M4700-14A

Supplier: United States Biological
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Mucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:100-1:250 Flow cytometry: 1:30 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: M4700-14A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: MUC-1, Polymorphic epithelial mucin, PEM, PEMT, Episialin, Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelial membrane antigen, EMA, H23AG, Peanut-reactive urinary mucin, PUM, Breast carcinoma-associated antigen DF3, CD227 antigen
References: 1. Parry S, et al, Biochem Biophys Res Commun 283(3): 715-20, 2001 2. Pochampalli MR et al., Oncogene, Sept 18, 2006 3. Kigure S, et al. Rinsho Byori 54(5): 447-52, 2006
Additional info: Recognizes human MUC1. Species crossreactivity: mouse and rat.

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