Home  >  Products  >  MCL1 (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Bcl-2-like Protein 3, Bcl2-L-3, Bcl-2-related Protein EAT/mcl1, mcl1/EAT, BCL2L3)
MCL1 (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Bcl-2-like Protein 3, Bcl2-L-3, Bcl-2-related Protein EAT/mcl1, mcl1/EAT, BCL2L3)

MCL1 (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Bcl-2-like Protein 3, Bcl2-L-3, Bcl-2-related Protein EAT/mcl1, mcl1/EAT, BCL2L3)

Cat no: M2749-01P

Supplier: United States Biological
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Mcl-1 (Myeloid cell leukemia-1) is a 37kD Bcl-2-related protein with an apparent molecular weight of 43kD on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-b1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunoprecipitation: 10-20ug/ml Immunohistochemistry: 10-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: M2749-01P
Reactivities: Human, Mouse, Rat, Canine, Feline, Non-Human Primate, Porcine, Rabbit
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human Mcl-1. Species Crossreactivity: mouse, rat, monkey, rabbit, porcine, feline and canine.

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