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Products MCAD Polyclonal Antibody
| Catalogue number: | 101730 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human recombinant MCAD{7568} |
| P type: | Antibodies|Fatty Acids|PPAR |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Medium-chain fatty acyl-CoA dehydrogenase (MCAD) is a mitochondrial enzyme that catalyzes the first step in the .beta.oxidation of fatty acids. MCAD expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. The promoter for MCAD contains a peroxisome proliferator response element (PPRE) and is regulated transcriptionally by peroxisome proliferator-activated receptor alpha (PPAR.alpha.), a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Because of this, MCAD expression can be used as a marker to evaluate the in vivo activity of PPAR.alpha. Human MCAD is approximately 87% homologous to porcine and rat MCAD, respectively. MCAD is expressed in liver, heart, kidney, and skeletal muscle. |
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