Home  >  Products  >  Macrophage, Monocyte Chemotactic Protein-1 (MCP-1, Chemokine C-C Motif Ligand 2, CCL2, GDCF-2, HC11, HSMCR30, JE, MGC9434, Monocyte Chemoattractant Protein 1, Monocyte Chemotactic and Activating Factor, Monocyte Chemotactic Protein 1, Monocyte Secretory P
Macrophage, Monocyte Chemotactic Protein-1 (MCP-1, Chemokine C-C Motif Ligand 2, CCL2, GDCF-2, HC11, HSMCR30, JE, MGC9434, Monocyte Chemoattractant Protein 1, Monocyte Chemotactic and Activating Factor, Monocyte Chemotactic Protein 1, Monocyte Secretory P

Macrophage, Monocyte Chemotactic Protein-1 (MCP-1, Chemokine C-C Motif Ligand 2, CCL2, GDCF-2, HC11, HSMCR30, JE, MGC9434, Monocyte Chemoattractant Protein 1, Monocyte Chemotactic and Activating Factor, Monocyte Chemotactic Protein 1, Monocyte Secretory P

Cat no: M1203-04D

Supplier: United States Biological
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Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: M1203-04D
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: As reported
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Yoshimura T. et al. 1989. FEBS Lett. 244:487-493. 2. Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56 3. Rollins B.J. et al. 1991. Genomics. 10:489-492
Additional info: Species Crossreactivity: Human. Other species have not been tested.

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