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LRP5, LRP6 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LRP7/Low-density Lipoprotein Receptor-related Protein 6, LRP-6)

LRP5, LRP6 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LRP7/Low-density Lipoprotein Receptor-related Protein 6, LRP-6)

Cat no: L2601-05V

Supplier: United States Biological
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LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and b-catenin stabilization. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: L2601-05V
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human LRP-5/6 at ~120kD and ~170kD. Species Crossreactivity: mouse.

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