Home  >  Products  >  Jip1 (C-Jun-amino-terminal Kinase-interacting Protein 1, JIP-1, JNK-interacting Protein 1, Islet-brain-1, IB-1, JNK MAP Kinase Scaffold Protein 1, Mitogen-activated Protein Kinase 8-interacting Protein 1, Mapk8ip1, Ib1, Mapk8ip, Prkm8ip)
Jip1 (C-Jun-amino-terminal Kinase-interacting Protein 1, JIP-1, JNK-interacting Protein 1, Islet-brain-1, IB-1, JNK MAP Kinase Scaffold Protein 1, Mitogen-activated Protein Kinase 8-interacting Protein 1, Mapk8ip1, Ib1, Mapk8ip, Prkm8ip)

Jip1 (C-Jun-amino-terminal Kinase-interacting Protein 1, JIP-1, JNK-interacting Protein 1, Islet-brain-1, IB-1, JNK MAP Kinase Scaffold Protein 1, Mitogen-activated Protein Kinase 8-interacting Protein 1, Mapk8ip1, Ib1, Mapk8ip, Prkm8ip)

Cat no: J2499-30F

Supplier: United States Biological
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JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: J2499-30F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes mouse JIP-1 at ~78kD and ~110kD. Species Crossreactivity: human and rat.

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