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Products HIF-1(alpha) (C-Term) Polyclonal Antibody
| Catalogue number: | 10006421 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | HIF-1.alpha. amino acids 809-826 |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Hypoxia inducible factor-1.alpha. (HIF-1.alpha.) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1.alpha. migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival. HIF-1.alpha. is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities. Cayman Chemical's HIF-1.alpha. polyclonal antibody can be used for WB analysis for HIF-1.alpha. on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested. |
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