Home  >  Products  >  Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7)
Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7)

Frizzled 7 (Frizzled-7, Frizzled (Drosophila) Homolog of 7, Frizzled Homolog 7, Fz 7, Fz-7, FZD7, FzE3, hFz7, Homolog of Drosophila Frizzled 7)

Cat no: F6401-30A

Supplier: United States Biological
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Applications: Suitable for use in Peptide ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Peptide ELISA: Antibody detection limit dilution 1:64,000. Western Blot: 0.3-1ug/ml; Approx 60kD band observed in lysates of cell lines HEK293 and HepG2 (calculated MW of 63.6kD according to NP_003498). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6401-30A
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Vincan E, Darcy PK, Farrelly CA, et al. Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. Oncogene. (2007) 5; 26:2340-2352.
Additional info: Recognizes human Frizzled 7 at ~63kD. Species Crossreactivity: mouse.

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