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Fragilis (Interferon-induced Transmembrane Protein 3, Interferon-inducible Protein 1-8U, IFITM3)

Fragilis (Interferon-induced Transmembrane Protein 3, Interferon-inducible Protein 1-8U, IFITM3)

Cat no: F6072-60D

Supplier: United States Biological
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Fragilis is an IFN-induced transmembrane protein that belongs to the highly conserved fragilis protein family. It consists of an N-terminal signal sequence, 2 putative transmembrane domains, 3 potential phosphorylation sites and C-terminal Leucine-zipper. It is expressed in early embryos and nascent primordial germ cells and is associated with Germ cell specification and development. It is cell surface protein and might be important in mediating interactions amongst germ cells and their surrounding neighbors. It is also suggested that it might be involved in anti-proliferative signaling and homotypic cell adhesion. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6072-60D
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Lange et.al BMC Dev Biol., 3: 1 (2003).
Additional info: Recognizes mouse Fragilis. Species Crossreactivity: rat.

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