Home  >  Products  >  Formyl Peptide Receptor 1 (FPR1, fMet-Leu-Phe Receptor, fMLP Receptor, FMLP, N-formyl Peptide Receptor, FPR, N-formylpeptide Chemoattractant Receptor)

Formyl Peptide Receptor 1 (FPR1, fMet-Leu-Phe Receptor, fMLP Receptor, FMLP, N-formyl Peptide Receptor, FPR, N-formylpeptide Chemoattractant Receptor)

Cat no: F6010-02A


Supplier: United States Biological
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Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection. (WO0157074) FPR1 has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Spleen Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6010-02A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human FPR1.

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