Home  >  Products  >  Flt3 (Fms-like Tyrosine Kinase 3, FLT-3, CD135, EC 2.7.10.1, FL Cytokine Receptor, FLK2, Fms-related Tyrosine Kinase 3, Stem Cell Tyrosine Kinase 1, STK1, STK-1, Tyrosine-protein Kinase Receptor FLT3)
Flt3 (Fms-like Tyrosine Kinase 3, FLT-3, CD135, EC 2.7.10.1, FL Cytokine Receptor, FLK2, Fms-related Tyrosine Kinase 3, Stem Cell Tyrosine Kinase 1, STK1, STK-1, Tyrosine-protein Kinase Receptor FLT3)

Flt3 (Fms-like Tyrosine Kinase 3, FLT-3, CD135, EC 2.7.10.1, FL Cytokine Receptor, FLK2, Fms-related Tyrosine Kinase 3, Stem Cell Tyrosine Kinase 1, STK1, STK-1, Tyrosine-protein Kinase Receptor FLT3)

Cat no: F4600-04

Supplier: United States Biological
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FMS-related tyrosine kinase 3 (FLT3, also called Flk2), a member of the type III receptor tyrosine kinase family that includes c-Kit, PDGF and M-CSF receptors, is expressed on early hematopoietic progenitor cells, and supports growth and differentiation within the hematopoietic system (1,2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream cellular targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4
Catalogue number: F4600-04
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Haylock, D.N. et al. (1997). Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand. Blood 90: 2260-2272. 2. Buhring, H-J. et al. (1998). CD135 (FLT3/FLK2/STK-1) workshop panel report. in Leucocyte Typing VI: White Cell Differentiation Antigens. Edited by kishimoto, T. et al. Garland Publishing pp 875-879.
Additional info: Recognizes human CD135 at ~155-160kD.

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