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Fibroblast Growth Factor 21, Rat, Mouse BioAssay(TM) ELISA Kit (FGF-21)

Cat no: F4212-92B

Supplier: United States Biological
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Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production by pancreatic b-cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. No significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls. Although considerable progress has been made in the understanding of the pathobiology of type 2 diabetes, as well in the development of new compounds for the treatment of diabetic patients, this disease remains a major global health concern. The insulin-independent activities of FGF-21, as well as the absence of the weight gain effects of insulin, thiazolidinediones and other anti-diabetic drugs, distinguish it from current insulin-sensitizing drugs, making it a promising therapeutic. Sensitivity: 49.4 pg/mL when using 10uL Mouse or 20uL Rat sample size. Precision: Intra-assay: (same/less than) 10% Inter-assay: (same/less than) 8% Accuracy: 85-102% Detection Method: Colorimetric Standard Curve Range: 50-12000pg/ml Kit Components: 1. Rat/Mouse FGF-21 ELISA Plate 1x96 wells 2. HRP Wash Buffer Concentrate, 10X 2x50ml 3. Rat/Mouse FGF-21 Standard, 1x1 vial 4. Control A ,1x1 vial 5. Control B ,1x1 vial 6. Matrix Solution, 1x1vial 7. Assay Buffer, 1x25ml 8. Detection Antibody (biotin), 1x1.2ml 9. Enzyme Solution, 1x12ml 10. Substrate (3, 3
Catalogue number: F4212-92B
Reactivities: Mouse, Rat
Applications: ELISA
Size: 1Kit

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