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FHOD1 (FH1/FH2 Domain-containing Protein 1, Formin Homolog Overexpressed in Spleen 1, FHOS, Formin Homology 2 Domain-containing Protein 1, FHOS, FHOS1)

FHOD1 (FH1/FH2 Domain-containing Protein 1, Formin Homolog Overexpressed in Spleen 1, FHOS, Formin Homology 2 Domain-containing Protein 1, FHOS, FHOS1)

Cat no: F6002-67A

Supplier: United States Biological
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FHOD1, a predominantly cytoplasmic protein, is a 1164aa containing member of formin:diaphanous family of proteins that contains a FH1 (formin homology 1) domain, a FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding:formin homology 3) domain. FHOD1 self-associates via the FH2 domain and binds to F-actin via its N-terminus and also to the cytoplasmic domain of CD21 via its C-terminus. Function of FHOD1 include the assembly of F-actin structures, such as stress fibers, and depends on the Rho-ROCK cascade for its activity. Reports suggest the role of FHOD1 in the coordination of microtubules with actin fibers and also in cell elongation. Endogenous FHOD1 interacts directly with Rac1 in a guanine nucleotide-independent manner and thus activates transcription from the serum response element. Ubiquitous expression of FHOD1 is seen in most of the tissues with abundance in the spleen and a variety of human cell lines. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6002-67A
Reactivities: Human, Mouse, Rat, Canine
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Westendorf, JJ. et al. J. Biol. Chem. 276:46453-46459 (2001). 2. Takeya, R. et al. J. Cell Sci. 116:4567-4575 (2003). 3. Beausoleil, SA. et al. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135 (2004). 4. Gasteier, JE. et al. Exp. Cell. Res. 306:192-202 (2005).
Additional info: Recognizes human FHOD1. Species Crossreactivity: chimpanzee, canine, equine, mouse, rat, rhesus monkey. Species sequence homology: bovine, opossum.

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