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FHOD1 (FH1/FH2 Domain-containing Protein 1, Formin Homolog Overexpressed in Spleen 1, FHOS, Formin Homology 2 Domain-containing Protein 1, FHOS, FHOS1)

FHOD1 (FH1/FH2 Domain-containing Protein 1, Formin Homolog Overexpressed in Spleen 1, FHOS, Formin Homology 2 Domain-containing Protein 1, FHOS, FHOS1)

Cat no: F6002-67

Supplier: United States Biological
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FHOD1 is a member of the formin homology (FH) family of proteins bearing significant homology to Formins and Diaphanous proteins in the FH1 and FH2 domains. FHOD1 contains all the conserved domains, including FH1, FH2, and FH3 domains, and a coiled-coil, characteristic of FH protein. It also contains two nuclear localization signals, a classic lysine:arginine-rich domain and a consensus bipartite signal. FHOD1 induces transcription from serum response factor by multiple pathways. It interacts with Rac1 GTPase and induces the formation of and associates with bundled actin stress fibers. The protein also coordinates microtubules with these actin stress fibers thus mediating cell elongation. RNA blot analysis revealed high levels of FHOD1 mRNA in the spleen, skeletal muscle, and lung. Human FHOD1 gene is localized in the chromosomal region 16q22. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6002-67
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Westendorf, JJ. et al. Gene. 232:173-182 (1999). 2. Jennifer, J. et al. J. Biol. Chem. 276:46453-46459 (2001). 3. Gasteier, JE. et al. Exp. Cell. Res. 306:192-202 (2005).
Additional info: Recognizes human FHOD1.

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