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Products DP1 Receptor Polyclonal Antibody
| Catalogue number: | 101640 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | mouse DP1 receptor N-terminal amino acids 2-21 |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | The DP1 receptor is one of two receptor isoforms for prostaglandin D2 (PGD2), a major cyclooxygenase metabolite of arachidonic acid. As a G-protein coupled receptor (GPCR), the receptor primarily couples to Gs to increase cAMP, but also transiently increases Ca2+, apparently through the cAMP pathway. DP1 receptor mRNA has been detected in various tissues and cells including brain, spleen, lung, bone marrow, stomach, skin, and mast cells, however little is know about its protein localization due to its low level of expression. Cayman's DP1 receptor polyclonal antibody detects the protein by western blot in samples such as cerebral cortex, hippocampus, and HT-29 cells, a colorectal cancer cell line shown to express this receptor. The antibody can also be used in immunocytochemistry/immunohistochemistry to detect DP1 receptor expression in cells and tissues. |
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