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Cat no: D9025-01

Supplier: United States Biological
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Doramectin is a biosynthetic avermectin derived from a mutant of the original Streptomyces avermitilis strain supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite. Source: Doramectin from Streptomyces sp., biosynthetic. Molecular Weight: ~899.1 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D9025-01
Size: 5mg
Form: Supplied as a white solid.
Purity: ~95% (HPLC)

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