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Products COX Polyclonal Antibody
| Catalogue number: | 160103 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | purified ovine COX-1 |
| P type: | Antibodies|Cyclooxygenase|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2 COX-1 is constitutively expressed in almost all animal tissues and is involved in the homeostatic role of eicosanoids. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions. COX-1 and -2 are 70 and 72 kDa proteins, respectively. Both cyclooxygenases have been cloned from a variety of species including human, mouse, rat, and sheep. COX-1 isoform at the amino acid level, whereas the homology between COX-1 and COX-2 is only about 60%. |
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