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Products COX-2 Monoclonal Antibody (Clone CX229)
| Catalogue number: | 160112 |
| Hosts: | Mouse |
| Applications: | Immunocytochemistry, Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human COX-2 amino acids 580-599 (NASSSRSGLDDINPTVLLKE){2} |
| P type: | Antibodies|Cyclooxygenase|Eicosanoids |
| Isotype: | IgG1 |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions. COX-2 is a 72kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep. |
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