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CD45RO (Leukocyte Common Antigen, LCA, Ly-5 T200) (PE)

Cat no: C2400-70D

Supplier: United States Biological
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Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RO isoform contains none of the alternatively spliced exons and is present on most thymocytes, a subpopulation of resting (memory) T cells within both CD4 and CD8 subsets as well as on monocytes and granulocytes. CD45RO plays an essential role in lymphocyte activation. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Formalin fixed paraffin embedded sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
Catalogue number: C2400-70D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 120Tests
Form: Supplied as a liquid in PBS, pH 7.2, 15% glycerol, 0.2% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
References: 1. S.H. Smith, et al, (1986) Immunology 58: 63-70. 2. M. Streulo, et al, (1988) J Immunol 141: 3910-3914. 3. M. Merkenschlager & P.C.L. Beverly, (1989) Intl Immunol 1: 450-459. I.S. 4. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol 12: 85-116. 5. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) 6. p. 386-399. D. Leitenberg, et al, (1996) J Exp Med 183: 249-259.
Additional info: Recognizes the CD45RO isoform of about 180kD.

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