Home  >  Products  >  CD18 (Beta 2 antigen CD18 (p95), Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 beta subunit, Complement receptor C3 beta subunit, Integrin beta 2, ITGB2, LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, LFA1, Lymphocyte function associated antig
CD18 (Beta 2 antigen CD18 (p95), Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 beta subunit, Complement receptor C3 beta subunit, Integrin beta 2, ITGB2, LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, LFA1, Lymphocyte function associated antig

CD18 (Beta 2 antigen CD18 (p95), Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 beta subunit, Complement receptor C3 beta subunit, Integrin beta 2, ITGB2, LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, LFA1, Lymphocyte function associated antig

Cat no: C2269-01V

Supplier: United States Biological
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In the immune system, integrins have essential roles in leukocyte trafficking and function. These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues (1). Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial for integrin-mediated signaling. JAB1 (Jun activation domain-binding protein 1), a coactivator of the c-Jun transcription factor, has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections (3) Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2269-01V
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Kellersch B, et al. Results Prob Cell Differ 43:245-57, 2006 2. Bianchi E, et al. Nature 404(6778):617-21, 2000 3. Nelson C, et al. J. Biol Chem 267(5):3351-7, 1992.
Additional info: Recognizes human LFA-beta 2.

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