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CD177 (Neutrophil Glycoprotein NB1) (APC)

Cat no: C2548-90B1

Supplier: United States Biological
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The neutrophil NB1 antigen is expressed by 97% of the caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: Neat; 10ul labels 10e6 cells in 100ul. Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Catalogue number: C2548-90B1
Reactivities: Human, Non-Human Primate
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a lyophilized powder from PBS, 1% BSA, 0.09% sodium azide. Labeled with Allophycocyanin (APC). Reconstitute with 1ml sterile ddH2O.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Caruccio, L. et al. (2003) Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy. Transfusion. 43: 357 - 363. 2. Kissel, K. et al. (2002) Molecular basis of NB1 (HNA-2a, CD177) deficiency. Blood. 99: 4231 - 4233. 3. Jerke, U. et al. (2010) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.J Biol Chem. Dec 30. 4. Dillon, M. et al. (2008) Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines. Leuk Res. 32: 811-9.
Additional info: Recognizes human CD177 (neutrophil glycoprotein NB1). Species Crossreactivity: Rhesus monkey

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