Home  >  Products  >  CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5) (FITC)
CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5) (FITC)

CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5) (FITC)

Cat no: C2548-84W3

Supplier: United States Biological
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Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. Functional Application: The antibody will block MLR, sgp39 induced human B cell proliferation and T cell dependent B cell differentiation. Applications: Suitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested. Recommended Dilution Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2548-84W3
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Western Blot
Size: 120Tests
Form: Supplied as a liquid in 50mM sodium phosphate pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 5% glycerol, 0.2% BSA, 0.04% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: CD40 Antigen Ligand, Hyper IgM Syndrome, T-B cell Activating Molecule
References: 1. D. Gray, et al, (1994) Seminars in Immunol 6: 303-310. 2. F. Pietravalle, et al, (1996) J Biol Chemistry 271: 5965-5967. 3. S.M.A. Lens, (1996) J Immunol 156: 507-514. 4. R.J. Noelle, (1996) Immunity 4: 415-419. 5. A. Desai-Mehta, et al, (1996) J Clin Invest 97: 2063-2073. 6. I.S. Grewal and R.A. Flavell, (1996) Immunol Today 17: 410-414. 7. K.M. Aagaard-Tillery and D.F. Jelinek, (1996) J Immunol 157 : 2769-2778.
Additional info: Iimmunoprecipitates a CD154 (gp39) molecule of about 39kD.

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