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Apoptosis Inducer Set, Ready-to-use, BioAssay(TM) (Actinomycin

Cat no: A2299-93

Supplier: United States Biological
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The set contains 5 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Actinomycin D, an antineoplastic antibiotic, inhibits RNA synthesis. Camptothecin, an inhibitor of nuclear topoisomerase, induces apoptosis in many types of cells. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Etoposide, a derivative of podophyllotoxin, inhibits topoisomerase activity. Kit Components: A2299-93A: Actinomycin D, 10mM 1x50ul A2299-93B: Camptothecin, 2mM
Catalogue number: A2299-93
Size: 1Kit
Form: Supplied as liquids in DMSO.
References: 1. Onishi, Y., et al., Biochem. Biophys. Acta 1175: 147-154 (1993). 2. Fearnhead, H.O., et al., Biochem. Pharmacol. 48: 1073-1079 (1994). 3. Martin, S.J., et al., J. Exp. Med. 182: 1545-1556 (1995). 4. Nicholson, D.W., et al., Nature 376: 37-40 (1995). 5. Suzuki, A. and M. Keto, Exp. Cell. Res. 227: 154-163 (1996).

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