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Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278)

Cat no: A2297-23

Supplier: United States Biological
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Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in an animal models. Source: Antibiotic LL Z1640-2 Molecular Weight: ~362.4 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2297-23
Size: 1mg
Form: Supplied as a white solid.
Purity: (same/more than) 95% by HPLC
Alternative names: Antibiotic C292, Antibiotic L 783278
References: 1. New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad, G.A., et al., J. Org. Chem. 43: 2339 (1978). 2. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. Ninomiya-Tsuji, J., et al., J. Biol. Chem. 278: 18,485 (2003).

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