The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function
Melting Point:
222-232C
Solubility:
DMSO, Methanol
Atmosphere:
Inert gas
Method for Determining Identity:
Proton NMR Spectroscopic Analysis
TLC Conditions:
SiO2: Dichloromethane: Methanol: NH4OH; 8ml: 2ml: 5 drops; Visualized with UV and KMnO4; Single spot; Rf=0.5.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.