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14-3-3, gamma (Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG)

14-3-3, gamma (Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG)

Cat no: 0014-07J

Supplier: United States Biological
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14-3-3 proteins are present as multigene families in most organisms. Signal-induced phosphorylation has the ability to change protein function. Sometimes, however, phosphorylation is not enough to change a protein's function. 14-3-3 proteins play an important role of bringing signal transduction to completion. They regulate many cellular processes that are important in cancer biology, such as apoptosis and cell-cycle checkpoints. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:3,000. Detects a band of ~ 33kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 0014-07J
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid. May contain azide. See Certificate of Analysis.
P type: Mab
Isotype: IgG2a
Purity: Mouse ascites
Alternative names: Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG
References: 1. Ferl, R.J. 14-3-3 proteins:regulation of signal-induced events. Physiol. Plant. 120(2):173-178, 2004. 2. Hermeking, H. The 14-3-3 cancer connection. Nature. 3:931-943, 2003. 3. Jin, Z., et al. Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis. J. Biol. Chem. 279(22):23837-23844, 2004. (Immunoprecipitation, western blot, human)
Additional info: Recognizes human 14-3-3 gamma. Reacts with the naturally occurring human form of 14-3-3 gamma, where the N-terminal Met is removed, resulting in an acetylated N-terminal Val. Unprocessed (non-modified) 14-3-3 gamma is not recognized by this antibody.

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