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Syndecan-4 (SYND4, Amphiglycan, Ryudocan Core Protein, SDC4)

Syndecan-4 (SYND4, Amphiglycan, Ryudocan Core Protein, SDC4)

Cat no: S9111-60A

Supplier: United States Biological
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Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan belonging to the syndecan proteoglycan family. Syndecan-4 functions as a receptor or coreceptors in intracellular signaling. The syndecan heparan sulfate chains of Syndecan-4 bind to HIV-1 gp120 and thus functions as trans HIV receptors. Thus endothelial cells lining the vasculature that are rich in Syndecan may provide a microenvironment to boost HIV replication in T cells. Reports suggest that Syndecan-4 is usually upregulated in skin dermis after wounding thus playing an important role in wound healing and angiogenesis. It is also needed in satellite cell function and in the development and regeneration of skeletal muscle. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9111-60A
Reactivities: Human, Mouse, Bovine, Canine, Chicken/Bird, Non-Human Primate
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Kojima T. et al. Biochem. Biophys. Res. Commun. 190: 814-822 (1993). 2. Echtermeyer F. et al. J. Clin. Invest. 107: R9-R14 (2001). 3. Bobardt M. D. et al. Immunity 18: 27-39 (2003).
Additional info: Recognizes human Syndecan-4. Species Crossreactivity: chicken, chimpanzee, bovine, canine, equine, monkey, mouse. Species sequence homology: pufferfish, salmon, xenopus, zebrafish.

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