Home  >  Products  >  Synaptotagmin 1, Phosphorylated (Ser309) (Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, P65) (Azide Free)
Synaptotagmin 1, Phosphorylated (Ser309) (Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, P65) (Azide Free)

Synaptotagmin 1, Phosphorylated (Ser309) (Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, P65) (Azide Free)

Cat no: S9109-19D

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Synaptotagmin 1 is a 60kD member of the synaptotagmin family, expressed in membranes of synaptic vesicles in rostral, phylogenetically younger brain regions and in some endocrine tissues. Ca2+ is bound by synaptogamin whose C2 domains then bind phospholipids, trafficking vesicles to the synaptic membrane and exocytosis. This results in fast synchronous neurotransmitter release. Synaptotagmin also binds neurexins, syntaxin and AP2 independently of Ca2+ binding. Phosphorylation of synaptotagmin by protein kinases is thought to modulate its activity Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9109-19D
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Xu, Jun. et al. (2007) Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons. Neuron. Volume 54:567-581. 2. Sullivan, J. (2007) Please Release Me. Neuron. Volume 54:493-494. 3. Hilfiker, S. et al. (1999) Regulation of synaptotagmin I phosphorylation by multiple protein kinases. J. Neurochem. 73:921-932.
Additional info: Recognizes rat synaptotagmin 1 when phosphorylated at Ser309. Species sequence homology: Bovine, Chicken, Human, Zebrafish, Mouse, Dog, Primate.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave