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SWAP70 (Switch-associated Protein 70, SWAP-70, HSPC321, KIAA0640)

SWAP70 (Switch-associated Protein 70, SWAP-70, HSPC321, KIAA0640)

Cat no: S8875-01E

Supplier: United States Biological
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SWAP70 is a 585aa regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of the SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Daudi Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8875-01E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Hilpela,P., Oberbanscheidt,P., Hahne,P., Hund,M., Kalhammer,G., Small,J.V. and Bahler,M. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol. Biol. Cell 14 (8), 3242-3253 (2003). 2. Masat,L., Caldwell,J., Armstrong,R., Khoshnevisan,H., Jessberger,R., Herndier,B., Wabl,M. and Ferrick,D. Association of SWAP-70 with the B cell antigen receptor complex. Proc. Natl. Acad. Sci. U.S.A. 97 (5), 2180-2184 (2000). 3. Rapalus,L., Minegishi,Y., Lavoie,A., Cunningham-Rundles,C. and Conley,M.E. Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency. Clin. Immunol. 101 (3), 270-275 (2001).
Additional info: Recognizes human SWAP70. Species sequence homology: mouse, bovine, chimpanzee, canine.

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