Home  >  Products  >  Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)
Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Cat no: S8500-01N

Supplier: United States Biological
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Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin. Applications: Suitable for use in Immunofluorescence and Immunohistochemistry. Not suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:200 for 2 hours on human prostate cells Immunohistochemistry (FFPE): 2-4ug/ml for 30 minutes at RT. Requires boiling tissue in 10mM citrate buffer for 10-20 minutes followed by cooling at RT for 10-20 minutes. Optimal dilutions to be determined by the researcher. Positive Control: HeLa cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8500-01N
Reactivities: Human, Rat
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 0.2% BSA.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Geddis, A., et al. Blood. 104: 1017-1024, 2004. 2. Zeng SX, Li Y, Jin Y et al. Mol Cell Biol. 2009.
Additional info: Recognizes human Survivin. Species Crossreactivity: rat

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