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Structural Maintenance of Chromosomes 1 Like 1, phosphorylated (Ser966) (SMC1, SMC1L1)

Cat no: S7980-01K

Supplier: United States Biological
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SMC1 is a member of the evolutionary highly conserved SMC family of ATPases which play a vital role in the organization of chromosomes during mitosis. Eukaryotic SMC1 combines with SMC3, and with the two sister-chromatid cohesion proteins Scc1 and Scc3, to form the macromolecular cohesion complex, responsible for the linking of sister chromatids during metaphase. The SMC1-SMC3 heterodimer also combines with DNA polymerase E and ligase III to form the DNA recombination complex RC-1. Applications: Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested Recommended Dilution: Immunoprecipitation: 2-6ug/mg lysate Western Blot: 1:500-1:5000detects a band of ~160kD in HeLa whole cell lysates. Optimal dilution to be determined by researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7980-01K
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquidi n TBS, 0.09% sodium azide and 0.1% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jones, S. and Sgouros, J. (2001) The cohesion complex: sequence homologies, interaction networks and shared motifs. Genome. Biol. (Research) 2: 1-12. 2. Kim, S.T. et al. (2002) Involvement of the cohesion complex protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16: 560-570.
Additional info: Recognizes the human nuclear protein SMC1 (structural maintenance of chromosomes 1), when phosphorylated at Ser966.

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