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STK11 (Serine/threonine-protein Kinase 11, Renal Carcinoma Antigen NY-REN-19, Serine/Threonine-protein Kinase LKB1, LKB1, PJS)

Cat no: S7973-58W8

Supplier: United States Biological
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The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium. LKB1 often migrates at a higher than expected molecular weight in SDSPAGE. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: PC-3 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7973-58W8
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Hemminki A, et al (1998) Nature. 391:184-7. 2. Boudeau J, et al (2003) EMBO J. 22:5102-14. 3. Hawley SA, et al (2003) J. Biol. 2:28. 4. Inoki K, et al (2003) Cell. 115:577-90. 5. Baas AF, et al (2004) Cell. 116:457-66.
Additional info: Recognizes human LKB1. Species Crossreactivity: mouse.

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