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STK11 (Serine/threonine-protein Kinase 11, Renal Carcinoma Antigen NY-REN-19, Serine/Threonine-protein Kinase LKB1, LKB1, PJS)

Cat no: S7973-58W6

Supplier: United States Biological
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LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7973-58W6
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Xenopus/Amphibian
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Bignell,G.R., Barfoot,R., Seal,S., Collins,N., Warren,W. and Stratton,M.R. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res. 58 (7), 1384-1386 (1998). 2. Jenne,D.E., Reimann,H., Nezu,J., Friedel,W., Loff,S., Jeschke,R., Muller,O., Back,W. and Zimmer,M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat. Genet. 18 (1), 38-43 (1998).
Additional info: Recognizes human LKB1. Species Crossreactivity: bovine, chicken, canine, mouse, rat, xenopus. Species sequence homology: chimpanzee.

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