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STAT5A/B, phosphorylated (Tyr694/699)

Cat no: S7972-07Q

Supplier: United States Biological
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The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation. Applications: Suitable for use in Western Blot. Not suitable for use in Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Positive Control: PDGF treated 3T3/NIH cells Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7972-07Q
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, 30% glycerol.
P type: Mab
Isotype: IgG
Purity: Tissue culture supernatant
References: 1. Gollob, J.A., et al., Blood 91: 1341-1354, 1998.
Additional info: Recognizes human STAT5A. Species Crossreactivity: mouse. Species sequence homology: chimpanzee, bovine, and rat.

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