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Stat 6, ID (Signal Transducer And Activator of Transcription 6, IL-4 Stat)

Cat no: S7972-42S

Supplier: United States Biological
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Signal Transducer and Activator of Transcription 6 (STAT6) is 119kD mediator of transcription in response to IL-4 and IL-13 stimulation. It resides in the cytoplasm in a latent form as a monomer protein. Active IL-4 engages SH2 binding domain of STAT6 that results in STAT6 phosphorylation at Tyr641 residue. Phosphorylated monomeric STAT6 dimerize via their N- terminal domain. Consequently dimeric STAT6 is translocated into the nucleus, binds target DNA sequence, and promotes transcription. It was demonstrated that normal STAT6 function is critical for commitment of CD4+ T cells to the Th2 phenotype and IgE response. Thus, mice deficient in STAT6 failed to produce IgE, were deficient in Th2 differentiation, and did not show allergic airway response. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-42S
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chem W et al. (2004) J. of Immun. 172: 6744-6750. 2. Tomkinson A et al. (1999) Am. J. Respir. Crit. Care Med. 160: 1283-1291. 3. Pesu M et al. (2000) Blood 95(2): 494-502. 4. Daines M et al. (2003) J. of Biol. Chem. 278(33): 30971- 30974.
Additional info: Recognizes human STAT6.

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