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STAT 5A (Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5, Mammary Gland Factor, MGF)

Cat no: S7972-08A

Supplier: United States Biological
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STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. Both Stat5a and Stat5b regulate interleukin-7 induced B-cell precursor expansion. Activation of the protein in myeloma and lymphoma associated with a TEL:JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. Human STAT5A gene is mapped to chromosome 17q11.2. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: HeLa cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-08A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Luo, G. et al. Mol. Endocrinol. 14:114-123 (2000). 2. Leonard, WJ. et al. Annu. Rev. Immunol. 16:293-322 (1998).
Additional info: Recognizes human STAT5A. Species Crossreactivity: mouse and rat.

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