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STAT 2 (Signal Transducer and Activator of Transcription 2)

Cat no: S7970-53

Supplier: United States Biological
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Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs (1-3). Additionally, upon activation, Stat-2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3gp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 (Mouse only) Immunohistochemistry: 1:50-1:100 Flow cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: S7970-53
Reactivities: Mouse
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris- Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Silvennoinen, O., Ihle, J. N., Schlessinger, J., and Levy, D. E. (1993) Nature 366, 583-585 2. Darnell, J. E., Jr. (1997) Science 277, 1630-1635 3. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., and Darnell, J. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8555-8559 4. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., and Levy, D. E. (1992) Mol. Cell. Biol. 12, 3315-3324
Additional info: Recognizes human STAT2. Species crossreactivity: mouse.

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