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STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)

Cat no: S7970-80E

Supplier: United States Biological
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STAT2 (signal transducer and activator of transcription #2) is a 98kD member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is associated with type I (a? and b--) interferon signaling. All STATs contain an N-terminal oligomerization domain, a DNA-binding domain, and an SH2-association region. STAT2 is phosphorylated at Y689 by receptor-associated Janus kinases (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription. Applications: Suitable for use in Western Blot and Flow Cytometry. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml Flow Cytometry: 2.5ug/10e6 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7970-80E
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Western Blot
Size: 50ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose, 0.1% sodium azide. Reconstitute with 250ul sterile PBS.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human phospho-STAT2 (Tyr689).

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