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Stargazin, CT (Ca2 Gamma Subunit of Voltage-gated Calcium Channel, Cacng2)

Cat no: S7968-30B

Supplier: United States Biological
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Stargazin is a 36kD member of the transmembrane AMPAR regulatory proteins (TARP) family, which plays a vital role in the regulation of the trafficking and localisation/targeting of synaptic AMPA (-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptors (AMPARs). AMPARs are a major group of ionotropic glutamate receptors, highly concentrated at the postsynaptic density (PSD) of excitatory synapses, which require strict regulation for the control of synaptic strength in the brain. Stargazin has been identified as a vital AMPAR-interacting protein which binds to AMPARs via its extracellular domain, whilst interacting with PDZ scaffolding proteins such as PSD-95, via a cytosolic C-terminal PDZ-binding motif. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7968-30B
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Cuadra, A.E. et al. (2004) AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST. J. Neurosci. 24: 7491-7502. 2. Choi, J. et al. (2002) Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95. J. Biol. Chem. 277: 12359-12363.
Additional info: Recognizes an epitope within the C-terminal region (CT) of rat stargazin. Species sequence homology: mouse

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